COVID, One Year Later: What Do We Know Now?

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We’re catching up with experts we talked to at the start of the pandemic and asking: what do we know now that we didn’t back then?

CDC guidance on masks:
https://www.cdc.gov/coronavirus/2019-ncov/prevent-getting-sick/diy-cloth-face-coverings.html

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Credits:
Executive Producers:
George Zaidan
Hilary Hudson

Producers:
Andrew Sobey
Elaine Seward

Writer/Host:
Sam Jones, PhD

Scientific consultants:
Leila Duman, PhD
Benjamin Neuman, PhD
Brianne Raccor, PhD
Shan Soe-Lin, PhD
Vincent Racaniello, PhD

Sources:
Continually updated mask guidelines
https://www.cdc.gov/coronavirus/2019-ncov/prevent-getting-sick/diy-cloth-face-coverings.html

Scientific Brief: Community Use of Cloth Masks to Control the Spread of SARS-CoV-2
https://www.cdc.gov/coronavirus/2019-ncov/more/masking-science-sars-cov2.html

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
https://www.sciencedirect.com/science/article/pii/S0092867420302294

Receptor binding and priming of the spike protein of SARS-CoV-2 for membrane fusion
https://www.nature.com/articles/s41586-020-2772-0

Final report confirms remdesivir benefits for COVID-19
https://www.nih.gov/news-events/nih-research-matters/final-report-confirms-remdesivir-benefits-covid-19#:~:text=Studies%20in%20cells%20and%20animals,interrupting%20production%20of%20the%20virus.

Cell entry mechanisms of SARS-CoV-2
https://www.pnas.org/content/117/21/11727

US: Fauci says CDC may recommend wearing two masks to fight virus
https://www.livemint.com/news/world/us-fauci-says-cdc-may-recommend-wearing-two-masks-to-fight-virus-11612284079702.html

Co-receptor
https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/co-receptor

Evidence that TMPRSS2 Activates the Severe Acute Respiratory Syndrome Coronavirus Spike Protein for Membrane Fusion and Reduces Viral Control by the Humoral Immune Response
https://jvi.asm.org/content/85/9/4122

Outcomes of Cardiovascular Magnetic Resonance Imaging in Patients Recently Recovered From Coronavirus Disease 2019 (COVID-19)
https://jamanetwork.com/journals/jamacardiology/fullarticle/2768916

WHO timeline
https://www.who.int/emergencies/diseases/novel-coronavirus-2019/interactive-timeline#!

Emerging SARS-CoV-2 Variants
https://www.cdc.gov/coronavirus/2019-ncov/more/science-and-research/scientific-brief-emerging-variants.html

Europe’s growing mask ask: Ditch the cloth ones for medical-grade coverings
https://www.washingtonpost.com/world/europe/europe-coronavirus-masks-regulations/2021/01/20/23463c08-5a74-11eb-a849-6f9423a75ffd_story.html

Time to double or upgrade masks as coronavirus variants emerge, experts say
https://www.washingtonpost.com/health/2021/01/27/double-mask-variants-guidance/

Antiviral Drugs That Are Approved or Under Evaluation for the Treatment of COVID-19
https://www.covid19treatmentguidelines.nih.gov/antiviral-therapy/

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