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Fevers are one of our best weapons against infections, but they don’t work like you might think.
We’d like to give a big thank you to Sharon Evans from the Roswell Park Comprehensive Cancer Center for sharing her expertise for this video!
To learn more about this topic, start your googling with these keywords:
Fever: a rise in body temperature, usually caused by infection
Heat shock proteins (HSP): a family of proteins that are produced by cells in response to exposure to stressful conditions
Neutrophils: white blood cells that play an important role in inflammation and are early responders to pathogens.
T cells: major components of the adaptive immune system whose roles include regulating the immune response to pathogens.
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Appenheimer, M.M. & Evans, S.S. (2018) Temperature and adaptive immunity. Handbook of Clinical Neurology 156: 397–415. https://linkinghub.elsevier.com/retrieve/pii/B978-0-444-63912-7.00024-2
Casadevall, A. (2016) Thermal Restriction as an Antimicrobial Function of Fever. PLoS Pathog 12(5): e1005577. https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1005577
ChangDong L. et al. (2019). Fever Promotes T Lymphocyte Trafficking via a Thermal Sensory Pathway Involving Heat Shock Protein 90 and α4 Integrins. Immunity 50(1):137-151. https://www.cell.com/immunity/fulltext/S1074-7613(18)30495-3
Evans, S.S. et al. (2015) Fever and the thermal regulation of immunity: the immune system feels the heat. Nature Reviews Immunology 15(6): 335+. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786079/
Hasday, J.D., Thompson, C., Singh, I.S. (2014) Fever, immunity, and molecular adaptations. Comprehensive Physiology 4:109–48. https://onlinelibrary.wiley.com/doi/10.1002/cphy.c130019
Hasday, J.D. & Singh, I.S. (2000) Fever and the heat shock response: distinct, partially overlapping processes. Cell Stress Chaperones 5:471–480. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC312879/
Javid, B., MacAry, P.A. & Lehner, P.J. (2007) Structure and function: heat shock proteins and adaptive immunity. Journal of Immunology 179:2035–2040. https://www.jimmunol.org/content/179/4/2035
Mackowiak, P. A.: Direct effects of hyperthermia on pathogenic microorganisms: teleological implications with regard to fever. Reviews of Infectious Diseases 1981, 3: 508–518. https://academic.oup.com/cid/article-abstract/3/3/508/307776